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Caldolor and Epiject Iv

Determining the interaction of Caldolor and Epiject Iv and the possibility of their joint administration.

Check result:

Caldolor <> Epiject Iv

Relevance: 20.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

High doses of ibuprofen (greater than 400 mg/day) may displace valproic acid from protein binding sites in vitro. This interaction may be more significant in uremic patients. Free valproic acid concentrations should be measured if toxicity is suspected.

References

Dasgupta A, Volk A "Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions." Ther Drug Monit 18 (1996): 284-7

Caldolor

Generic Name: ibuprofen

Brand name: Caldolor, NeoProfen, Advil, Advil Liqui-Gels, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength

Synonyms: n.a.

What is Caldolor?

Epiject Iv

Generic Name: valproic acid

Brand name: Depakene, Depacon, Stavzor, Valproate Sodium

Synonyms: Valproic acid, Valproic Acid and Derivatives

What is Epiject Iv?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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