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Caldolor and Phenytoin Chewable Tablets

Determining the interaction of Caldolor and Phenytoin Chewable Tablets and the possibility of their joint administration.

Check result:

Caldolor <> Phenytoin Chewable Tablets

Relevance: 20.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

One case report has suggested that ibuprofen may cause phenytoin toxicity. However, data have been conflicting: one pharmacokinetic study did not demonstrate an effect and another study demonstrated that ibuprofen displaces phenytoin from protein binding sites in vitro. The clinical significance is unknown. Clinical and laboratory monitoring for altered phenytoin effect is recommended.

References

Bachmann KA, Schwartz JI, Forney RB Jr, et al "Inability of ibuprofen to alter single dose phenytoin disposition." Br J Clin Pharmacol 21 (1986): 165-9
Sandyk R "Phenytoin toxicity induced by interaction with ibuprofen." S Afr Med J 62 (1982): 592
Dasgupta A, Timmerman TG "In vitro displacement of phenytoin from protein binding by nonsteroidal antiinflammatory drugs tolmetin, ibuprofen, and naproxen in normal and uremic sera." Ther Drug Monit 18 (1996): 97-9

Caldolor

Generic Name: ibuprofen

Brand name: Caldolor, NeoProfen, Advil, Advil Liqui-Gels, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength

Synonyms: n.a.

What is Caldolor?

Phenytoin Chewable Tablets

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin Chewable Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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