Caldolor and Rybix ODT

• Generic Name: ibuprofen
• Dosage Forms: intravenous injection
• Other Brand Names: Caldolor, NeoProfen, Advil, Advil Liqui-Gels, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength

Caldolor injection (ibuprofen) is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Caldolor injection is used to reduce fever and treat pain.

Caldolor may also be used for purposes not listed in this medication guide. Neoprofen, another brand of ibuprofen injection, is used in premature babies to treat a condition called patent ductus arteriosus (an abnormal blood vessel opening that normally closes shortly after birth).

• Generic Name: tramadol
• Dosage Forms: tablet, orally disintegrating
• Other Brand Names: ConZip, Ultram, Ultram ER, Rybix ODT, Ryzolt

Tramadol is used to relieve moderate to moderately severe pain, including pain after surgery. The extended-release capsules or tablets are used for chronic ongoing pain.

Tramadol belongs to the group of medicines called opioid analgesics. It acts in the central nervous system (CNS) to relieve pain.

When tramadol is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program.