Calquence and Dexlansoprazole Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

By reducing the acidity level in the stomach, dexlansoprazole may interfere with the absorption of acalabrutinib and reduce its effectiveness. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact or interact to a lesser extent. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with proton pump inhibitors may significantly decrease the oral bioavailability of acalabrutinib and reduce its concentrations in plasma. The solubility of acalabrutinib is pH-dependent and decreases with increasing pH. According to the product labeling, acalabrutinib is freely soluble in water at pH below 3 and practically insoluble at pH above 6. Coadministration with omeprazole 40 mg for 5 days decreased acalabrutinib systemic exposure (AUC) by 43% in healthy subjects. Due to the long-lasting effect of proton pump inhibitors, separation of dosing may not eliminate the interaction with acalabrutinib.

MANAGEMENT: Concomitant use of acalabrutinib with proton pump inhibitors should generally be avoided. If acid suppression therapy is required, antacids and H2-receptor antagonists should be considered, with dosing separated by a couple hours from acalabrutinib dosing.

Calquence

Generic Name: acalabrutinib

Brand name: Calquence

Synonyms: n.a.

What is Calquence?

Dexlansoprazole Capsules

Generic Name: dexlansoprazole

Brand name: Dexilant, Kapidex

Synonyms: Dexlansoprazole

What is Dexlansoprazole Capsules?