Calquence and DuoDote

• Generic Name: acalabrutinib
• Dosage Forms: capsule, gelatin coated
• Other Brand Names: Calquence

Calquence (acalabrutinib) blocks the action of certain enzymes in the body, which can interfere with the growth and spread of cancer cells.

Calquence is used to treat mantle cell lymphoma (a type of non-Hodgkin lymphoma) in adults. This medicine is given after other treatments have failed.

Calquence was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, patients responded to this medicine. However, further studies are needed.

Calquence is also used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in adults.

• Generic Name: atropine / pralidoxime
• Dosage Forms: injection
• Other Brand Names: ATNAA, DuoDote

Atropine blocks the action of a certain chemical that may reach high levels in the body after a poisoning. Atropine also stimulates the heart and reduces the secretions of the nose, mouth, and lungs to improve breathing.

Pralidoxime reverses muscle weakness or paralysis caused by a poison or nerve agent.

DuoDote is a combination medicine used as an antidote to treat poisoning by a pesticide (insect spray) or a chemical that interferes with the central nervous system, such as nerve gas.

DuoDote is not effective as an antidote for all types of pesticide poisonings. You may need medications or additional treatments.

DuoDote may also be used for purposes not listed in this medication guide.