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Caltrate 600+D Soft Chews and UpSpringbaby D

Determining the interaction of Caltrate 600+D Soft Chews and UpSpringbaby D and the possibility of their joint administration.

Check result:
Caltrate 600+D Soft Chews <> UpSpringbaby D
Relevance: 06.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ergocalciferol together with cholecalciferol should generally be avoided unless otherwise directed by your doctor. Both of these medications are forms of vitamin D, and taking too much vitamin D can lead to toxic effects related to excessive calcium levels in the blood and urine, such as irregular heart rhythm, seizures, kidney stones, and eventual calcification of blood vessels, cornea, and soft tissues of the body. If you take digoxin, a common heart medication, having a high blood level of calcium can also increase the risk of developing digoxin toxicity. Talk to your doctor if you have any questions or concerns. You will need close monitoring of your calcium and phosphorus levels to safely use these medications. You should avoid an abrupt increase in your dietary calcium intake, and seek medical attention if you experience early symptoms of vitamin D intoxication such as weakness, fatigue, headache, drowsiness, vertigo, ringing in the ears, loss of appetite, nausea, vomiting, constipation, dry mouth, metallic taste, muscle pain, bone pain, muscle incoordination, and low muscle tone. Late symptoms may include frequent urination, excessive thirst, weight loss, conjunctivitis ("pink eye"), light sensitivity, runny nose, itching, increased body temperature, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Due to a narrow therapeutic index, vitamin D analogs given in combination with each other or with pharmacologic doses of vitamin D may demonstrate additive effects resulting in toxicity manifested as hypercalcemia, hypercalciuria, and hyperphosphatemia. Progressive hypercalcemia due to overdosage of vitamin D and its metabolites can be dangerous and sufficiently severe as to require emergency attention. Acute hypercalcemia may exacerbate tendencies for cardiac arrhythmias and seizures and may potentiate the action of digitalis drugs. Chronic hypercalcemia can lead to generalized vascular calcification, nephrocalcinosis, and calcifications of the cornea or other soft tissues. Immobilized patients are particularly vulnerable to the risk of hypercalcemia.

MANAGEMENT: Vitamin D analogs should not be used in combination with each other or with pharmacologic doses of vitamin D. Serum calcium and phosphorus levels must be closely monitored during therapy with a vitamin D analog, especially early in treatment during dosage adjustment. The serum calcium X phosphorus product should be maintained at less than 55 in patients with chronic kidney disease and should not be allowed to exceed 70 in any patient. An estimate of daily dietary calcium intake should be made and the intake adjusted when indicated. Patients should be advised to avoid an abrupt increase in dietary calcium intake, as it may trigger hypercalcemia, and to contact their physician if they experience early symptoms of vitamin D intoxication associated with hypercalcemia such as weakness, fatigue, headache, somnolence, vertigo, tinnitus, anorexia, nausea, vomiting, constipation, dry mouth, metallic taste, muscle pain, bone pain, ataxia, and hypotonia. Late symptoms may include polyuria, polydipsia, weight loss, nocturia, conjunctivitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, and cardiac arrhythmias. Radiographic evaluation of suspect anatomical regions may be useful in the early detection of hypercalcemia. If hypercalcemia develops, treatment with vitamin D and any calcium product should be stopped immediately.

References
  • "Product Information. Hectorol (doxercalciferol)." Genzyme Corporation, Cambridge, MA.
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • "Product Information. One-Alpha (alfacalcidol)." Pharmel Inc, Montreal, IN.
  • "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
  • "Product Information. Zemplar (paricalcitol)." Abbott Pharmaceutical, Abbott Park, IL.
Caltrate 600+D Soft Chews

Generic Name: calcium / vitamin d

Brand name: Calcitrate with D, Caltrate 600+D Soft Chews, Citracal + D, Os-Cal Extra D3, Oystercal-D, UpCal D, Os-Cal 250 with D, Oysco D, Dical-D, Calcet, Oyster Shell Calcium with Vitamin D, O-Cal-D, Oyster-D, Oyst-Cal-D, Caltro with Vitamin D, Oysco 500 with D, Oysco D with Calcium, Os-Cal with D, Caltrate 600 with D, Calcarb with D, Posture-D H/P, Dical Captabs, Dicalphos plus D, Os-Cal 500 with D, Caltrate 600 with D Plus Soy, Caltrate Colon Health, Calvite P & D, Sedecal D, Chewable Calcium with Vitamin D, Osteocit D Plus, Os-Cal 500 + D, Citracal Petites, Citracal Creamy Bites, Citracal 250 mg + D, Calcio Del Mar, Citrus Calcium with Vitamin D, Calcium 600+D, Risacal-D, Liquid Calcium with Vitamin D, Citracal Maximum + D, Citracal Calcium + D Slow Release 1200, Citracal Calcium Gummies, Caltrate Gummy Bites, Super Calcium 600 + D3 400, Os-Cal Calcium+D3, Caltrate 600 + D, Citracal Regular, Calcet Petites, Calcium 500+D, D3 with Calcium, Calcitrate, Caltrate 600+D, Os-Cal 500+D, Os-Cal 500+Extra D Chewable

Synonyms: n.a.

UpSpringbaby D

Generic Name: cholecalciferol

Brand name: Carlson D, Ddrops, Decara, Enfamil D-Vi-Sol, Replesta, Thera-D 2000, UpSpringbaby D, Vitamin D3, Aqueous Vitamin D, Bio-D-Mulsion, Bio-D-Mulsion Forte, BProtected Pedia D-Vite, D-Vi-Sol, Dialyvite Vitamin D 5000, Dialyvite Vitamin D3 Max, Pronutrients Vitamin D3, Opurity Vitamin D, VitaJoy Daily D Gummies, D3 Dots, VitaMelts Vitamin D

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle