Canagliflozin and Metformin Extended-Release Tablets and Digoxin oral/injection
Determining the interaction of Canagliflozin and Metformin Extended-Release Tablets and Digoxin oral/injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using digoxin together with metFORMIN may increase the effects of metFORMIN, which may lead to a life-threatening condition called lactic acidosis This can cause weakness, increasing sleepiness, slow heart rate, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. Talk with your doctor before using digoxin while you are using metFORMIN. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Digoxin is a cationic drug and theoretically could decrease the excretion of metformin by competing for renal tubular transport. Although this interaction has not been specifically reported for digoxin, cimetidine (also a cationic drug) has been reported to interact with metformin in this manner. In addition, patients who are being pharmacologically treated for congestive heart failure appear to be at greater risk of developing lactic acidosis.
MANAGEMENT: If digoxin and metformin must be used together, particularly slow and cautious titration of metformin dosage is recommended. The maximal dose of metformin probably also should be reduced until further information about this interaction is available. Patients should be advised to promptly notify their physician if they experience malaise, myalgia, respiratory distress, hyperventilation, slow or irregular heartbeat, somnolence, abdominal upset, or other unusual symptoms.
- Somogyi A, Stockley C, Keal J, Rolan P, Bochner F "Reduction of metformin renal tubular secretion by cimetidine in man." Br J Clin Pharmacol 23 (1987): 545-51
- "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: canagliflozin / metformin
Brand name: Invokamet, Invokamet XR
Synonyms: Canagliflozin and metformin, Canagliflozin and Metformin
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: Digoxin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Canagliflozin and Metformin Extended-Release Tablets-Digoxin Tablets
- Canagliflozin and Metformin Extended-Release Tablets-Dihydro CP Syrup
- Canagliflozin and Metformin Extended-Release Tablets-Dihydrocodeine BPM Phenyleph HCl
- Canagliflozin and Metformin Extended-Release Tablets-Dihydrocodeine, Aspirin, and Caffeine
- Canagliflozin and Metformin Extended-Release Tablets-Dihydroergotamine
- Canagliflozin and Metformin Extended-Release Tablets-Dihydroergotamine injection
- Digoxin oral/injection-Canagliflozin and Metformin Tablets
- Digoxin oral/injection-Canakinumab
- Digoxin oral/injection-Canakinumab Subcutaneous
- Digoxin oral/injection-Canasa
- Digoxin oral/injection-Canasa Pac rectal
- Digoxin oral/injection-Canasa rectal