Canagliflozin and Metformin Extended-Release Tablets and Seconal Sodium

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Secobarbital may decrease the blood levels of canagliflozin, which may make the medication less effective in treating your diabetes. Monitor your blood sugar levels closely, and talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with uridine diphosphoglucuronate-glucuronosyltransferase (UGT) inducers such as rifampin, phenytoin, phenobarbital, and ritonavir may decrease area under the curve (AUC) of canagliflozin by up to 51%. This may decrease efficacy of canagliflozin.

MANAGEMENT: If coadministration with a UGT inducer is required, consider increasing the dosage of canagliflozin to 300 mg once daily in patients who are currently tolerating 100 mg once daily, have an eGFR greater than 60 mL/min and require additional glycemic control. Other glycemic therapy should be considered for patients with a lower eGFR.

Canagliflozin and Metformin Extended-Release Tablets

Generic Name: canagliflozin / metformin

Brand name: Invokamet, Invokamet XR

Synonyms: Canagliflozin and metformin, Canagliflozin and Metformin

What is Canagliflozin and Metformin Extended-Release Tablets?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?