Canakinumab and Rilonacept

• Generic Name: canakinumab
• Dosage Forms: n.a.
• Other Brand Names: Ilaris

Canakinumab is a monoclonal antibody that blocks certain proteins in the body that can affect inflammation and other immune responses. Canakinumab is used to treat certain types of periodic fever syndromes, sometimes called auto-inflammatory syndromes.

Periodic fever syndromes are rare and often inherited conditions caused by mutations in certain genes; usually genes that are involved in producing a certain protein or enzyme in the body. People with a periodic fever syndrome have episodes of fever and inflammation without other causes such as infection or virus.

Canakinumab is used to treat the following periodic fever syndromes in adults and children who are at least 4 years old:

• Cryopyrin-Associated Periodic Syndromes (CAPS), including Familial Cold Autoinflammatory Syndrome and Muckle-Wells Syndrome.
• Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS).
• Hyperimmunoglobulin D Syndrome (HIDS), also called Mevalonate Kinase Deficiency (MKD).
• Familial Mediterranean Fever (FMF).

Canakinumab is also used to treat Sudden Juvenile Idiopathic Arthritis (SJIA) in children who are at least 2 years old.

Canakinumab may also be used for purposes not listed in this medication guide.

• Generic Name: rilonacept
• Dosage Forms: n.a.
• Other Brand Names: Arcalyst

Rilonacept is used to treat some of the symptoms of rare genetic conditions such as Familial Cold Auto-inflammatory Syndrome (FCAS) or Muckle-Wells Syndrome (MWS).

FCAS and MWS are inflammatory disorders in which the body develops certain symptoms without a known cause (such as virus, bacteria, or illness). These symptoms include fever, chills, fatigue, and joint pain. More serious symptoms may involve the bones and joints, the central nervous system (deafness, vision loss, mental impairment), or major organs such as the kidneys.

Rilonacept may treat or prevent the symptoms of Familial Cold Auto-inflammatory Syndrome (FCAS) or Muckle-Wells Syndrome (MWS). However, this medication is not a cure for these inherited conditions.

Rilonacept may also be used for purposes not listed in this medication guide.