Canasa Pac rectal and Coumadin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using warfarin and mesalamine. This combination may alter the effects of warfarin. Call your doctor promptly if you have any signs of blood clots (e.G., chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity) or bleeding (e.G., headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools). You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

MONITOR: Coadministration with mesalamine may potentiate or diminish the hypoprothrombinemic effects of warfarin. The mechanism of this interaction is unknown. In a case report where concomitant use resulted in a failure to attain a hypoprothrombinemic effect, the reporting clinician speculated that mesalamine may have complexed with warfarin, preventing warfarin's intestinal absorption or metabolism. Clinical data are lacking, particularly regarding effects on other oral anticoagulants. Whether rectally administered mesalamine will interfere with warfarin is unknown.

MANAGEMENT: Until additional information is available, patients receiving mesalamine along with an anticoagulant should be closely monitored. The INR and/or prothrombin time should be checked frequently and the warfarin dosage adjusted accordingly, particularly following initiation, change of dosage, or discontinuation of mesalamine. Patients should be advised to promptly report any signs of bleeding (e.g., headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools) or blood clots (e.g., chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity) to their healthcare provider. It should be noted that some authorities consider the use of mesalamine with anticoagulants to be contraindicated.

Canasa Pac rectal

Generic Name: mesalamine

Brand name: Canasa, Canasa Pac, Rowasa, SfRowasa, Apriso, Asacol HD, Delzicol, Lialda, Pentasa

Synonyms: Canasa Pac (rectal)

What is Canasa Pac rectal?

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?