CanesOral and Vfend

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using voriconazole together with fluconazole. Combining these medications is generally not recommended and may significantly increase the blood levels and effects of voriconazole. The interaction can also occur if you start voriconazole immediately or shortly after you stop using fluconazole. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with fluconazole may significantly increase the plasma concentrations of voriconazole. The mechanism is fluconazole inhibition of CYP450 2C9 and 3A4, the isoenzymes responsible for the metabolic clearance of voriconazole. When oral voriconazole (400 mg every 12 hours on day 1, then 200 mg every 12 hours for 2.5 days) was given in combination with oral fluconazole (400 mg on day 1, then 200 mg every 24 hours for 4 days) in six healthy male subjects, voriconazole peak plasma concentration (Cmax) and systemic exposure (AUC) increased by an average of 57% and 79%, respectively. In a follow-up clinical study involving 8 healthy male subjects, reduced dosages and/or dosing frequency of voriconazole and fluconazole did not eliminate or diminish this effect.

GENERALLY AVOID: Both fluconazole and voriconazole can cause QT interval prolongation. Coadministration may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death.

MANAGEMENT: Concomitant administration of fluconazole and voriconazole at any dosage is not recommended. Close monitoring for adverse events related to voriconazole is recommended if voriconazole is used sequentially after fluconazole, especially within 24 hours of the last dose of fluconazole.

CanesOral

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Fluconazole

What is CanesOral?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?