Capastat and Fenoprofen Calcium

• Generic Name: capreomycin
• Dosage Forms: injection, powder, for solution
• Other Brand Names: Capastat Sulfate

Treatment of active (clinical) tuberculosis (TB) in conjunction with other antituberculosis agents.

Second-line agent used in treatment of drug-resistant TB caused by Mycobacterium tuberculosis known or presumed to be susceptible to capreomycin.

For initial treatment of active TB caused by drug-susceptible M. tuberculosis, recommended multiple-drug regimens consist of an initial intensive phase (2 months) and a continuation phase (4 or 7 months). Although the usual duration of treatment for drug-susceptible pulmonary and extrapulmonary TB (except disseminated infections and TB meningitis) is 6–9 months, ATS, CDC, and IDSA state that completion of treatment is determined more accurately by the total number of doses and should not be based solely on the duration of therapy. A longer duration of treatment (e.g., 12–24 months) usually is necessary for infections caused by drug-resistant M. tuberculosis.

Patients with treatment failure or drug-resistant M. tuberculosis, including multidrug-resistant (MDR) TB (resistant to both isoniazid and rifampin) or extensively drug-resistant (XDR) TB (resistant to both isoniazid and rifampin and also resistant to a fluoroquinolone and at least one parenteral second-line antimycobacterial such as capreomycin, kanamycin, or amikacin), should be referred to or managed in consultation with experts in the treatment of TB as identified by local or state health departments or CDC.

• Generic Name: fenoprofen
• Dosage Forms: n.a.
• Other Brand Names: Nalfon, ProFeno, Fenortho, ProFeno

Consider potential benefits and risks of fenoprofen therapy as well as alternative therapies before initiating therapy with the drug. Use lowest possible effective dosage and shortest duration of therapy consistent with patient’s treatment goals.

Relief of mild to moderate pain in adults.

Symptomatic treatment of osteoarthritis and rheumatoid arthritis.

Has been used in the symptomatic treatment of juvenile rheumatoid arthritis.

Also has been used with some success in the treatment of ankylosing spondylitis and acute gouty arthritis.