Capecitabine and Sorafenib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

SORAfenib may increase the blood levels of capecitabine. This may increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, mouth sores, heart problems, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to experience anemia, bleeding problems, or infections due to low blood cell counts. You should contact your doctor if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Also seek immediate medical attention if you experience signs and symptoms that may suggest heart problems such as coughing, difficulty breathing, fluid retention, swelling, chest pain, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with sorafenib may increase the plasma concentrations of capecitabine and its active metabolite, 5-fluorouracil (5-FU). The mechanism of interaction has not been described. According to the sorafenib labeling, concomitant use of capecitabine (750 to 1050 mg/m2 twice daily on days 1 to 14 every 21 days) with sorafenib (200 or 400 mg twice daily continuously) increased capecitabine exposure by 15% to 50% and 5-FU exposure by 0% to 52%. The clinical significance of these modest changes is unknown. Sorafenib pharmacokinetics were not significantly altered by capecitabine.

MANAGEMENT: Caution may be advisable when capecitabine is used with sorafenib. Patients should be monitored closely for potential toxicities of capecitabine such as diarrhea, hand and foot syndrome, hyperbilirubinemia, myelosuppression and cardiotoxicity, and the dosage adjusted accordingly.

Capecitabine

Generic Name: capecitabine

Brand name: Xeloda

Synonyms: n.a.

What is Capecitabine?

Sorafenib

Generic Name: sorafenib

Brand name: Nexavar

Synonyms: SORAfenib

What is Sorafenib?