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Caprelsa and Omeprazole Delayed-Release Capsules

Determining the interaction of Caprelsa and Omeprazole Delayed-Release Capsules and the possibility of their joint administration.

Check result:

Caprelsa <> Omeprazole Delayed-Release Capsules

Relevance: 24.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The use of vandetanib with proton pump inhibitors may theoretically reduce its gastrointestinal absorption. Vandetanib exhibits pH-dependent solubility, with increased solubility at lower pH. The clinical significance is unknown. In healthy subjects, no clinically significant changes in the Cmax and AUC of vandetanib occurred, after coadministration of a single dose of vandetanib with five daily doses of omeprazole, or after coadministration of a single dose of vandetanib and two doses of ranitidine 12 hours apart. Dose adjustments are not required when vandetanib is administered with omeprazole or ranitidine.

References

EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
"Product Information. Vandetanib (vandetanib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Caprelsa

Generic Name: vandetanib

Brand name: Caprelsa

Synonyms: n.a.

What is Caprelsa?

Omeprazole Delayed-Release Capsules

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Zegerid>, Prilosec, Prilosec OTC

Synonyms: Omeprazole

What is Omeprazole Delayed-Release Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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