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Capreomycin Injection and Pancuronium

Determining the interaction of Capreomycin Injection and Pancuronium and the possibility of their joint administration.

Check result:

Capreomycin Injection <> Pancuronium

Relevance: 11.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using pancuronium together with capreomycin can prolong the effects of pancuronium. You should be closely monitored for prolong breathing cessation and respiratory paralysis after use of capreomycin. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Like other polypeptide antibiotics, capreomycin may prolong apnea and respiratory paralysis after use of neuromuscular blocking agents. The mechanism may be related to decreased intracellular potassium or decreased ionized serum calcium. In some cases, intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B.

MANAGEMENT: Patients should be closely monitored for signs of excessive and/or extended neuromuscular blockade.

References

Kronenfeld MA, Thomas SJ, Turndorf H "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology 65 (1986): 93-4
Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
"Product Information. Capastat Sulfate (capreomycin)." Dura Pharmaceuticals, San Diego, CA.
Huang KC, Heise A, Shrader AK, Tsueda K "Vancomycin enhances the neuromuscular blockade of vecuronium." Anesth Analg 71 (1990): 194-6

Capreomycin Injection

Generic Name: capreomycin

Brand name: Capastat Sulfate

Synonyms: Capreomycin

What is Capreomycin Injection?

Pancuronium

Generic Name: pancuronium

Brand name:

Synonyms: n.a.

What is Pancuronium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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