Capsagel Maximum Strength and Ramipril
Determining the interaction of Capsagel Maximum Strength and Ramipril and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Concomitant use of ACE inhibitors and capsaicinoid topical products may potentiate the cough associated with these agents individually. In 16 healthy volunteers, pretreatment with oral captopril (25 mg) two hours before inhalation of nebulized incremental doses of capsaicin (0.5 to 20 micromol/L in normal saline) resulted in a significant shift of the dose-response curve to capsaicin compared to pretreatment with placebo. The geometric mean dose of capsaicin causing 20 coughs per minute was 1.3 micromol/L for captopril and 2.8 micromol/L for placebo. In a case report, a 53-year-old woman who had been treated with an ACE inhibitor for several years complained of cough each time she applied a 0.075% capsaicin cream to her lower extremities. The patient had not experienced a cough during treatment with the ACE inhibitor alone. However, capsaicin alone may also induce coughing.
- Hakas JF Jr "Topical capsaicin induces cough in patient receiving ACE inhibitor." Ann Allergy 65 (1990): 322-3
- Morice AH, Brown MJ, Lowry R, Higenbottam T "Angiotensin-converting enzyme and the cough reflex." Lancet 2 (1987): 1116-8
Generic Name: capsaicin topical
Brand name: Capsagel, Capsagel Extra Strength, Capsagel Maximum Strength, Capzasin, Capzasin-HP, Zostrix-HP, Dolorac, RT Capsin, Capzasin-HP Arthritis Formula, Drs Cream, Analgesic Balm with Capsaicin, Axsain, Zostrix Neuropathy, Capzasin Quick Relief, Zostrix Foot Pain, Zostrix Maximum Strength, Zostrix Maximum Strength Foot Pain, Zostrix High Potency Foot Pain, Zostrix High Potency Arthritis Pain, Salonpas-Hot, Qutenza
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Capsagel Maximum Strength-Ramipril Tablets
- Capsagel Maximum Strength-Ramucirumab
- Capsagel Maximum Strength-Ramucirumab Intravenous
- Capsagel Maximum Strength-Ranexa
- Capsagel Maximum Strength-Ranibizumab
- Capsagel Maximum Strength-Ranibizumab Intraocular
- Ramipril-Capsagel Topical
- Ramipril-Capsagesic-HP Arthritis Relief Topical
- Ramipril-Capsaicin
- Ramipril-Capsaicin 8% Patch
- Ramipril-Capsaicin and diclofenac topical
- Ramipril-Capsaicin and Menthol Cream and Gel