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Captopril and Nitropress

Determining the interaction of Captopril and Nitropress and the possibility of their joint administration.

Check result:
Captopril <> Nitropress
Relevance: 11.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The dosage of nitroprusside required to achieve a given hypotensive response is significantly reduced when captopril is coadministered. The mechanism is unknown. Since the risk of side effects from nitroprusside may be significantly decreased with lower doses, this interaction may be advantageous.

References
  • Woodside J Jr, Garner L, Beford RF, et al "Captopril reduces the dose requirement for sodium nitroprusside induced hypotension." Anesthesiology 60 (1984): 413-7
Captopril

Generic Name: captopril

Brand name: Capoten

Synonyms: n.a.

Nitropress

Generic Name: nitroprusside

Brand name: Nitropress, Nipride RTU

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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