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Carafate (Sucralfate Oral Suspension) and Zorvolex

Determining the interaction of Carafate (Sucralfate Oral Suspension) and Zorvolex and the possibility of their joint administration.

Check result:
Carafate (Sucralfate Oral Suspension) <> Zorvolex
Relevance: 10.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Sucralfate may delay or decrease the pharmacologic effects of oral diclofenac. The mechanism may be related to reduced absorption. Data have conflicting and some studies suggest that sucralfate may have a protective effect on the gastric mucosa when taken with NSAIDs. Patients may be advised to take diclofenac 2 hours before or 6 hours after sucralfate if the interaction is to be avoided.

References
  • Pedrazzoli Junior J, Pierossi M de A, Muscara MN, Dias HF, da Silva CM, Mendes FD, de Nucci G "Short-term sucralfate administration alters potassium diclofenac absorption in healthy male volunteers." Br J Clin Pharmacol 43 (1997): 104-8
Carafate (Sucralfate Oral Suspension)

Generic Name: sucralfate

Brand name: Carafate

Synonyms: Carafate

Zorvolex

Generic Name: diclofenac

Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle