Carbachol ophthalmic and Larotrectinib Sulfate

• Generic Name: carbachol ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Isopto Carbachol, Miostat, Carboptic, Carbastat

Carbachol lowers pressure in the eye by increasing the amount of fluid that drains from the eye.

Carbachol ophthalmic (for the eye) is used to reduce pressure inside the eye after cataract surgery.

Carbachol ophthalmic may also be used for purposes not listed in this medication guide.

• Generic Name: larotrectinib
• Dosage Forms: n.a.
• Other Brand Names: Vitrakvi

Treatment of solid tumors harboring an NTRK fusion (without a known acquired mutation for resistance) in patients who have metastatic disease or may experience severe morbidity following surgical resection and whose disease progressed following prior therapy or those who are not candidates for other treatment options (designated an orphan drug by FDA for these cancers).

Accelerated approval based on overall response rate and duration of response. Continued approval may be contingent on verification and description of clinical benefit in confirmatory studies.

Confirmation of the presence of NTRK fusion is necessary prior to initiation of therapy. In clinical studies, NTRK fusion status of tumor specimens was determined by fluorescence in situ hybridization (FISH), reverse transcription-polymerase chain reaction (RT-PCR), or next-generation sequencing (NGS).