Carbamazepine and Dextromethorphan, Acetaminophen, and Diphenhydramine Liquid
Determining the interaction of Carbamazepine and Dextromethorphan, Acetaminophen, and Diphenhydramine Liquid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using acetaminophen together with carBAMazepine may alter the effects of acetaminophen and cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited data suggest that carbamazepine may increase the potential hepatotoxicity of acetaminophen and decrease its pharmacologic effects. The mechanism may be related to accelerated CYP450 metabolism of acetaminophen with consequent increase of hepatotoxic metabolites. This interaction is of greatest concern in cases of acetaminophen overdose.
MANAGEMENT: Until more information is available, the use of this combination over a prolonged period of time should probably be avoided. Monitoring for clinical and laboratory evidence of hepatotoxicity is recommended.
- Miners JO, Attwood J, Birkett DJ "Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways." Clin Pharmacol Ther 35 (1984): 480-6
- Perucca E, Richens A "Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs." Br J Clin Pharmacol 7 (1979): 201-6
- Smith JA, Hine ID, Beck P, Routledge PA "Paracetamol toxicity: is enzyme induction important?" Hum Toxicol 5 (1986): 383-5
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: CarBAMazepine
Generic Name: acetaminophen / dextromethorphan / diphenhydramine
Brand name: Diabetic Tussin Night Time Formula, Diabetic Tussin Night Time Cold & Flu
Synonyms: Acetaminophen, dextromethorphan, and diphenhydramine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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