Drug search by name

Carbamazepine and Seconal Sodium

Determining the interaction of Carbamazepine and Seconal Sodium and the possibility of their joint administration.

Check result:

Carbamazepine <> Seconal Sodium

Relevance: 23.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with a barbiturate may decrease the plasma concentrations of carbamazepine and increase concentrations of its active 10,11-epoxide metabolite. The mechanism is barbiturate induction of CYP450 3A4, the isoenzyme responsible for the metabolism of carbamazepine to carbamazepine-10,11-epoxide (CBZ-E). In clinical and pharmacokinetic studies, carbamazepine levels were typically lower when the drug was administered with phenobarbital than when administered alone, and CBZ-E levels generally higher. However, one study reported an increased clearance and reduced half-life of single-dose CBZ-E in six epileptic patients who were receiving phenobarbital compared to six drug-free healthy volunteers, which would seem to suggest an induction of CBZ-E metabolism also. The clinical significance of these changes are unknown, particularly since the anticonvulsant activity of CBZ-E relative to the parent compound has not been established. Until more data are available, it may be reasonable to monitor serum carbamazepine levels more closely whenever a barbiturate (if used for more than a few days) is added to or withdrawn from therapy.

References

Benetello P, Furlanut M "Primidone-carbamazepine interaction: clinical consequences." Int J Clin Pharmacol Res 7 (1987): 165-8
Eichelbaum M, Kothe KW, Hoffmann F, von Unruh GE "Kinetics and metabolism of carbamazepine during combined antiepileptic drug therapy." Clin Pharmacol Ther 26 (1979): 366-71
Cereghino JJ, Brock JT, Van Meter JC, et al "The efficacy of carbamazepine combinations in epilepsy." Clin Pharmacol Ther 18 (1975): 733-41
Tomson T, Spina E, Wedlund JE "Minor additive inducing effects of phenobarbital on carbamazepine clearance in patients on combined carbamazepine-phenytoin therapy." Ther Drug Monit 9 (1987): 117-9
Liu H, Delgado MR "Interactions of phenobarbital and phenytoin with carbamazepine and its metabolites' concentrations, concentration ratios, and level dose ratios in epileptic children." Epilepsia 36 (1995): 249-54
Dam M, Jensen A, Christiansen J "Plasma level and effect of carbamazepine in grand mal and psychomotor epilepsy." Acta Neurol Scand S75 (1975): 33-8
Spina E, Martines C, Fazio A, Trio R, Pisani F, Tomson T "Effect of phenobarbital on the pharmacokinetics of carbamazepine-10, 11-epoxide, an active metabolite of carbamazepine." Ther Drug Monit 13 (1991): 109-12
Ramsay RE, McManus DQ, Guterman A, et al "Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy." Ther Drug Monit 12 (1990): 235-41
"Product Information. Tegretol (carbamazepine)." Novartis Pharmaceuticals, East Hanover, NJ.

Carbamazepine

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: CarBAMazepine

What is Carbamazepine?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions