Carbamazepine Chewable and Pazopanib Hydrochloride
Determining the interaction of Carbamazepine Chewable and Pazopanib Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using PAZOPanib together with carBAMazepine. Combining these medications may decrease the blood levels and effects of PAZOPanib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations and pharmacologic effects of pazopanib, which is primarily metabolized by the isoenzyme.
MANAGEMENT: The use of pazopanib in combination with potent CYP450 3A4 inducers such as carbamazepine, dexamethasone, enzalutamide, phenobarbital, phenytoin, rifamycins, and St. John's wort should generally be avoided. Alternative treatment lacking CYP450 3A4-inducing activity should be considered in patients receiving pazopanib; otherwise, pazopanib should not be used. Other known CYP450 3A4 inducers include aminoglutethimide, barbiturates, bexarotene, bosentan, dabrafenib, efavirenz, nafcillin, nevirapine, somatrem, somatropin, and various other anticonvulsants, although the extent to which they may interact with pazopanib is unknown.
- "Product Information. Votrient (pazopanib)." GlaxoSmithKline, Research Triangle Park, NC.
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: pazopanib
Brand name: Votrient
Synonyms: Pazopanib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine Chewable-PB Hyos Elixir
- Carbamazepine Chewable-PCE
- Carbamazepine Chewable-PCE Dispertab
- Carbamazepine Chewable-PCM-LA
- Carbamazepine Chewable-Pedia Care Multi-Symptom Cold
- Carbamazepine Chewable-Pedia Poly-Vite Drops with Iron
- Pazopanib Hydrochloride-Carbamazepine Chewable Tablets
- Pazopanib Hydrochloride-Carbamazepine ER
- Pazopanib Hydrochloride-Carbamazepine Extended-Release Capsules (Carbatrol)
- Pazopanib Hydrochloride-Carbamazepine Extended-Release Capsules (Equetro)
- Pazopanib Hydrochloride-Carbamazepine Extended-Release Tablets
- Pazopanib Hydrochloride-Carbamazepine Intravenous