Carbamazepine ER and Midazolam Syrup
Determining the interaction of Carbamazepine ER and Midazolam Syrup and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using carBAMazepine and midazolam together may alter the effectiveness of midazolam. If you take both medications together, tell your doctor if midazolam is not effective. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Some antiepileptic agents such as carbamazepine and phenytoin significantly reduce the effect of oral midazolam. The mechanism may be due to enhanced gut and liver metabolism of midazolam (via CYP450 3A4 enzyme induction by carbamazepine). Parenteral midazolam is not likely to be affected. Other oral benzodiazepines metabolized by the 3A4 isoenzyme may interact similarly.
MANAGEMENT: Patients receiving this combination should be monitored for clinical response. Alternative oral sedative hypnotics may be preferable in patients receiving carbamazepine.
- Vajda FJ, Prineas RJ, Lovell RR "Interaction between phenytoin and the benzodiazepines." Br Med J 1 (1971): 346
- Shuttleworth E, Wise G, Paulson G "Choreoathetosis and diphenylhydantoin intoxication." JAMA 230 (1974): 1170-1
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: midazolam
Brand name: Versed, Nayzilam
Synonyms: Midazolam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine ER-Midodrine
- Carbamazepine ER-Midodrine Hydrochloride
- Carbamazepine ER-Midol
- Carbamazepine ER-Midol Caffeine Free
- Carbamazepine ER-Midol Complete
- Carbamazepine ER-Midol Extended Relief
- Midazolam Syrup-Carbamazepine Extended-Release Capsules (Carbatrol)
- Midazolam Syrup-Carbamazepine Extended-Release Capsules (Equetro)
- Midazolam Syrup-Carbamazepine Extended-Release Tablets
- Midazolam Syrup-Carbamazepine Intravenous
- Midazolam Syrup-Carbamazepine Oral Suspension
- Midazolam Syrup-Carbamazepine Tablets