Carbamazepine ER and Rapamune Tablets
Determining the interaction of Carbamazepine ER and Rapamune Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:CarBAMazepine may significantly reduce the blood levels of sirolimus, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 and/or P-glycoprotein may significantly decrease the plasma concentrations and pharmacologic effects of sirolimus. The mechanism probably involves reduced absorption as well as accelerated clearance of sirolimus due to induction of both intestinal P-glycoprotein drug efflux transporter and hepatic/intestinal CYP450 3A4 isoenzymes. In a study of 14 healthy volunteers, a potent inducer of CYP450 3A4 and P-gp, rifampin (600 mg daily for 14 days) increased the oral clearance of sirolimus (20 mg single dose) by 5.5-fold, representing mean decreases in peak blood concentration (Cmax) and area under the concentration-time curve (AUC) of 71% and 82%, respectively.
MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant levels, the use of sirolimus with potent inducers of CYP450 3A4 and/or P-gp is not recommended. Alternative therapeutic agents with less enzyme induction potential should be considered.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Rapamune (sirolimus)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: sirolimus
Brand name: Rapamune
Synonyms: Sirolimus
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine ER-Rapiflux
- Carbamazepine ER-Rapivab
- Carbamazepine ER-Raptiva
- Carbamazepine ER-Rasagiline
- Carbamazepine ER-Rasagiline Mesylate
- Carbamazepine ER-Rasburicase
- Rapamune Tablets-Carbamazepine Extended-Release Capsules (Carbatrol)
- Rapamune Tablets-Carbamazepine Extended-Release Capsules (Equetro)
- Rapamune Tablets-Carbamazepine Extended-Release Tablets
- Rapamune Tablets-Carbamazepine Intravenous
- Rapamune Tablets-Carbamazepine Oral Suspension
- Rapamune Tablets-Carbamazepine Tablets