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Carbamazepine Extended-Release Capsules (Carbatrol) and Ethosuximide Capsules

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Ethosuximide Capsules and the possibility of their joint administration.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Ethosuximide Capsules

Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Carbamazepine may decrease serum levels of ethosuximide. The mechanism is related to carbamazepine induction of ethosuximide metabolism. The clinical significance of this potential interaction is unknown.

References

Giaccone M, Bartoli A, Gatti G, Marchiselli R, Pisani F, Latella MA, Perucca E "Effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetics in epileptic patients." Br J Clin Pharmacol 41 (1996): 575-9
Warren JW Jr, Benmaman JD, Wannamaker BB, Levy RH "Kinetics of a carbamazepine-ethosuximide interaction." Clin Pharmacol Ther 28 (1980): 646-51

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Ethosuximide Capsules

Generic Name: ethosuximide

Brand name: Zarontin

Synonyms: Ethosuximide

What is Ethosuximide Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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