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Carbamazepine Extended-Release Capsules (Carbatrol) and Felbatol

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Felbatol and the possibility of their joint administration.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Felbatol

Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using carBAMazepine together with felbamate may alter the effects of both medications. Contact your doctor if you experience a worsening of seizure control or signs of carBAMazepine toxicity, including nausea, visual disturbances, dizziness, or loss of muscle coordination. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Felbamate may increase the plasma clearance of carbamazepine but decrease the plasma clearance of carbamazepine epoxide (the metabolite that is one of the principal causes of carbamazepine side effects). Increased plasma carbamazepine epoxide levels may result. Additionally, carbamazepine may cause a 50% increase in the plasma clearance of felbamate.

MANAGEMENT: When combination therapy is started, felbamate should be initiated at 1200 mg per day in 3 to 4 divided doses while reducing the carbamazepine dose by 20% to 30%. In general, the felbamate dose may be titrated more quickly than when felbamate is given as monotherapy. Close observation for clinical and laboratory evidence of altered effects is indicated. Patients should be advised to report worsening of seizure control or signs of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) to their physician.

References

Graves NM, Holmes GB, Fuerst RH, Leppik IE "Effect of felbamate on phenytoin and carbamazepine serum concentrations." Epilepsia 30 (1989): 225-9
"Product Information. Felbatol (felbamate)." Wallace Laboratories, Cranbury, NJ.
Wagner ML, Graves NM, Marienau K, Holmes GB, Remmel RP, Leppik IE "Discontinuation of phenytoin and carbamazepine in patients receiving felbamate." Epilepsia 32 (1991): 398-406
Albani F, Theodore WH, Washington P, Devinsky O, Bromfield E, Porter RJ, Nice FJ "Effect of felbamate on plasma levels of carbamazepine and its metabolites." Epilepsia 32 (1991): 130-2
Fuerst RH, Graves NM, Leppik IE, Brundage RC, Holmes GB, Remmel RP "Felbamate increases phenytoin but decreases carbamazepine concentrations." Epilepsia 29 (1988): 488-91
Wagner ML, Remmel RP, Graves NM, Leppik IE "Effect of felbamate on carbamazepine and its major metabolites." Clin Pharmacol Ther 53 (1993): 536-43

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Felbatol

Generic Name: felbamate

Brand name: Felbatol

Synonyms: n.a.

What is Felbatol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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