Carbamazepine Extended-Release Capsules (Carbatrol) and GNP Cold Relief Plus
Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and GNP Cold Relief Plus and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using acetaminophen together with carBAMazepine may alter the effects of acetaminophen and cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited data suggest that carbamazepine may increase the potential hepatotoxicity of acetaminophen and decrease its pharmacologic effects. The mechanism may be related to accelerated CYP450 metabolism of acetaminophen with consequent increase of hepatotoxic metabolites. This interaction is of greatest concern in cases of acetaminophen overdose.
MANAGEMENT: Until more information is available, the use of this combination over a prolonged period of time should probably be avoided. Monitoring for clinical and laboratory evidence of hepatotoxicity is recommended.
- Miners JO, Attwood J, Birkett DJ "Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways." Clin Pharmacol Ther 35 (1984): 480-6
- Perucca E, Richens A "Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs." Br J Clin Pharmacol 7 (1979): 201-6
- Smith JA, Hine ID, Beck P, Routledge PA "Paracetamol toxicity: is enzyme induction important?" Hum Toxicol 5 (1986): 383-5
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: acetaminophen / chlorpheniramine / phenylephrine
Brand name: Cold Relief Plus, EQL Effervescent Plus Cold, GNP Cold Relief Plus, QC Cold Relief Plus, Alka-Seltzer Plus Cold, Comtrex Severe Cold & Sinus, Contac Cold+Flu Maximum Strength, Dristan Cold Multi Symptom Formula, Robitussin Nighttime Nasal Relief, Tylenol Allergy Multi-Symptom, Tylenol Children's Plus Cold, Tylenol Sinus Congestion Nighttime, Contac Cold/Flu Day & Night, Coricidin D Cold/Flu/Sinus, Dristan Cold, Medicidin-D, Onset Forte, Robitussin Peak Cold Nasal Relief, Super Cold Tabs, Super Strength Sinadrin, Tylenol Sinus Congestion/Pain
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine Extended-Release Capsules (Carbatrol)-GNP Day Time D Cold/Flu
- Carbamazepine Extended-Release Capsules (Carbatrol)-GNP Mercuroclear
- Carbamazepine Extended-Release Capsules (Carbatrol)-GNP Pre-Menstrual Relief Max Strength
- Carbamazepine Extended-Release Capsules (Carbatrol)-GNP Tussin Night Time
- Carbamazepine Extended-Release Capsules (Carbatrol)-Gocovri
- Carbamazepine Extended-Release Capsules (Carbatrol)-Gold Sodium Thiomalate
- GNP Cold Relief Plus-Carbamazepine Extended-Release Capsules (Equetro)
- GNP Cold Relief Plus-Carbamazepine Extended-Release Tablets
- GNP Cold Relief Plus-Carbamazepine Intravenous
- GNP Cold Relief Plus-Carbamazepine Oral Suspension
- GNP Cold Relief Plus-Carbamazepine Tablets
- GNP Cold Relief Plus-Carbaphen 12