Carbamazepine Extended-Release Capsules (Carbatrol) and Itraconazole Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using carBAMazepine together with itraconazole may alter the effects of both medications. Contact your doctor if you experience increased side effects such as nausea, visual disturbances, dizziness, and loss of muscle coordination or if your infection worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration with carbamazepine may result in decreased plasma concentrations of the azole antifungal agents, itraconazole and ketoconazole. The mechanism is accelerated azole clearance due to induction of the CYP450 3A4 enzymatic pathway by carbamazepine. Treatment failure associated with substantially reduced and possibly subtherapeutic plasma concentrations of itraconazole has been reported during concurrent therapy with carbamazepine. Conversely, both itraconazole and ketoconazole are potent inhibitors of CYP450 3A4 and may increase the plasma levels of carbamazepine by inhibiting its metabolism. In a pharmacokinetic study involving eight patients with epilepsy stabilized on carbamazepine therapy, plasma concentrations of carbamazepine increased by an average of 29% following administration of ketoconazole (200 mg/day orally for 10 days) and returned to baseline following discontinuation of ketoconazole.

MANAGEMENT: Because of these mutual effects, caution is advised if itraconazole or ketoconazole must be used concomitantly with carbamazepine. Patients should be monitored for carbamazepine toxicity and antifungal treatment failure and dose adjustments may be required. Alternatively, other antifungal agents which are less likely to interact may be considered (e.g., terbinafine or fluconazole). Patients should be advised to report signs of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) to their physicians.

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Itraconazole Tablets

Generic Name: itraconazole

Brand name: Onmel, Sporanox, Sporanox PulsePak, Tolsura

Synonyms: Itraconazole

What is Itraconazole Tablets?