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Carbamazepine Extended-Release Capsules (Carbatrol) and Jardiance

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Jardiance and the possibility of their joint administration.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Jardiance

Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration of empagliflozin with inducers of uridine diphosphate glucuronosyl transferase (UGT) enzymes may decrease the plasma concentrations and efficacy of empagliflozin, which is primarily metabolized in vitro by UGT1A3, 1A8, 1A9, and 2B7. The effect of UGT induction on empagliflozin has not been studied. MANAGEMENT: Coadministration of empagliflozin with UGT inducers should be avoided if possible. If concomitant use is required, dosage adjustments as well as increased clinical and laboratory monitoring should be considered whenever a UGT inducer is added to or withdrawn from empagliflozin therapy. References "Product Information. Glyxambi (empagliflozin-linagliptin)." Boehringer Ingelheim, Ridgefield, CT. "Product Information. Jardiance (empagliflozin)." Boehringer Ingelheim, Ridgefield, CT. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0 View all 4 references

Professional:

GENERALLY AVOID: Coadministration of empagliflozin with inducers of uridine diphosphate glucuronosyl transferase (UGT) enzymes may decrease the plasma concentrations and efficacy of empagliflozin, which is primarily metabolized in vitro by UGT1A3, 1A8, 1A9, and 2B7. The effect of UGT induction on empagliflozin has not been studied.

MANAGEMENT: Coadministration of empagliflozin with UGT inducers should be avoided if possible. If concomitant use is required, dosage adjustments as well as increased clinical and laboratory monitoring should be considered whenever a UGT inducer is added to or withdrawn from empagliflozin therapy.

References

"Product Information. Glyxambi (empagliflozin-linagliptin)." Boehringer Ingelheim, Ridgefield, CT.
"Product Information. Jardiance (empagliflozin)." Boehringer Ingelheim, Ridgefield, CT.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Jardiance

Generic Name: empagliflozin

Brand name: Jardiance

Synonyms: n.a.

What is Jardiance?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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