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Carbamazepine Extended-Release Capsules (Carbatrol) and Limbitrol

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Limbitrol and the possibility of their joint administration.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Limbitrol

Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking carBAMazepine, tell your doctor if you also use amitriptyline. You may need dose adjustments or special tests in order to safely take both medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Carbamazepine may decrease serum concentrations of tricyclic antidepressants. The mechanism may be related to carbamazepine induction of CYP450 enzymes responsible for tricyclic antidepressant metabolism. Serum concentrations of carbamazepine may be increased by an unknown mechanism. Carbamazepine toxicity has been reported with desipramine. Additionally, tricyclic antidepressants may counteract the anticonvulsant effects of carbamazepine by lowering the seizure threshold.

MANAGEMENT: Clinical monitoring of serum concentrations, patient response, seizure control, and tolerance is recommended whenever either agent is added to or discontinued from an existing regimen, or when the dosage is changed.

References

Brosen K, Kragh-Sorensen P "Concomitant intake of nortriptyline and carbamazepine." Ther Drug Monit 15 (1993): 258-60
Brown CS, Wells BG, Cold JA, Froemming JH, Self TH, Jabbour JT "Possible influence of carbamazepine on plasma imipramine concentrations in children with attention deficit hyperactivity disorder." J Clin Psychopharmacol 10 (1990): 359-62
Jerling M, Bertilsson L, Sjoqvist F "The use of therapeutic drug monitoring data to document kinetic drug interactions: an example with amitriptyline and nortriptyline." Ther Drug Monit 16 (1994): 1-2
Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E "The effect of carbamazepine on the 2-hydroxylation of desipramine." Psychopharmacology (Berl) 117 (1995): 413-6
Leinonen E, Lillsunde P, Laukkanen V, Ylitalo P "Effects of carbamazepine on serum antidepressant concentrations in psychiatric patients." J Clin Psychopharmacol 11 (1991): 313-8

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Limbitrol

Generic Name: amitriptyline / chlordiazepoxide

Brand name: Limbitrol, Limbitrol DS

Synonyms: n.a.

What is Limbitrol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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