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Carbamazepine Extended-Release Capsules (Carbatrol) and Mesantoin

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Mesantoin and the possibility of their joint administration.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Mesantoin

Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking carBAMazepine, tell your doctor if you also use mephenytoin. You may need dose adjustments or special tests in order to safely take both medications together. This combination may alter the effects of the medication in your body. You should notify your doctor if you have loss of seizure control or symptoms such as drowsiness, visual problems, changes in behavior, nausea, or poor muscle coordination. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Hydantoins may decrease carbamazepine levels, and carbamazepine may have variable effects on hydantoin levels. The mechanism may be related to induction of CYP450 hepatic metabolism of carbamazepine and alteration of hydantoin metabolism.

MANAGEMENT: Close observation for clinical and laboratory evidence of altered effects is recommended, particularly when one drug is started or discontinued. Patients should be advised to notify their physician if they experience loss of seizure control or symptoms of hydantoin toxicity (drowsiness, visual disturbances, change in mental status, nausea, or ataxia).

References

Morris JC, Dodson E, Hatlelid JM, Ferrendelli JA "Phenytoin and carbamazepine, alone and in combination: anticonvulsant and neurotoxic effects." Neurology 37 (1987): 1111-8
Perucca E, Richens A "Reversal by phenytoin of carbamazepine-induced water intoxication: a pharmacokinetic interaction." J Neurol Neurosurg Psychiatry 43 (1980): 540-5
Ramsay RE, McManus DQ, Guterman A, et al "Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy." Ther Drug Monit 12 (1990): 235-41
Hansen JM, Siersbaek-Nielsen K, Skovsted L "Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man." Clin Pharmacol Ther 12 (1971): 539-43
Zielinski JJ, Haidukewych D, Leheta BJ "Carbamazepine-phenytoin interaction: elevation of plasma phenytoin concentrations due to carbamazepine comedication." Ther Drug Monit 7 (1985): 51-3
Zielinski JJ, Haidukewych D "Dual effects of carbamazepine-phenytoin interaction." Ther Drug Monit 9 (1987): 21-3
Gratz ES, Theodore WH, Newmark ME, Kupferberg HJ, Porter RJ, Qu Z "Effect of carbamazepine on phenytoin clearance in patients with complex partial seizures." Neurology 32 (1982): a223

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Mesantoin

Generic Name: mephenytoin

Brand name:

Synonyms: n.a.

What is Mesantoin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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