Carbamazepine Extended-Release Capsules (Carbatrol) and Mifepristone Tablets (For Ending Early Pregnancy)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using carBAMazepine together with miFEPRIStone can alter the blood levels and effects of both medications. Specifically, miFEPRIStone levels may decrease, which may make the medication less effective. At the same time, carBAMazepine levels may increase. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of mifepristone with a drug that is both a substrate as well as inducer of CYP450 3A4 may result in decreased plasma concentrations of mifepristone and increased plasma concentrations of the other drug. Mifepristone itself is a substrate and inhibitor of CYP450 3A4. Theoretically, mifepristone may inhibit metabolism of the coadministered drug while its own metabolism may be induced by the coadministered drug.

MANAGEMENT: When a drug that is both a substrate as well as inducer of CYP450 3A4 is coadministered with mifepristone, the possibility of diminished therapeutic response to mifepristone should be considered. In addition, clinical and/or laboratory monitoring for potentially increased pharmacologic effects of the concomitant drug may be appropriate. Because mifepristone is eliminated slowly from the body, drug interactions may be observed for a prolonged period following discontinuation (approximately 2 to 3 weeks if mifepristone had been administered chronically to steady state).

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Mifepristone Tablets (For Ending Early Pregnancy)

Generic Name: mifepristone

Brand name: Korlym, Mifeprex

Synonyms: Mifepristone

What is Mifepristone Tablets (For Ending Early Pregnancy)?