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Carbamazepine Extended-Release Capsules (Carbatrol) and Niacinamide

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Niacinamide and the possibility of their joint administration.

Check result:
Carbamazepine Extended-Release Capsules (Carbatrol) <> Niacinamide
Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Case reports suggest that nicotinamide may increase carbamazepine levels. The mechanism may be related to nicotinamide-induced inhibition of carbamazepine metabolism. Close observation for clinical and laboratory evidence of carbamazepine toxicity is recommended if these drugs must be used together. Patients should be advised to report signs of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) to their physicians.

References
  • Bourgeois BF, Dodson WE, Ferrendellis JA "Interactions between primidone, carbamazepine, and nicotinamide." Neurology 32 (1982): 1122-6
Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

Niacinamide

Generic Name: niacinamide

Brand name: Endur-Amide

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.