Carbamazepine Extended-Release Capsules (Carbatrol) and Oxcarbazepine Suspension

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may reduce the blood levels and effects of OXcarbazepine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with potent CYP450 inducers may decrease the plasma concentrations of the pharmacologically active 10-monohydroxy metabolite of oxcarbazepine known as MHD. Administration of oxcarbazepine 900 mg/day in combination with carbamazepine 400 to 2000 mg/day has resulted in an average reduction of MHD plasma concentrations by approximately 40%. Phenytoin 250 to 500 mg/day and phenobarbital 100 to 150 mg/day have reduced the plasma concentrations of MHD on average by approximately 30% and 25%, respectively, when oxcarbazepine was coadministered at 600 to 1800 mg/day. Since MHD is responsible for much of the pharmacologic effects of oxcarbazepine, the potential for altered anticonvulsant activity should be considered. Oxcarbazepine had no significant effect on the pharmacokinetics of carbamazepine and phenobarbital, but increased the plasma concentrations of phenytoin by 40% when administered at dosages greater than 1200 mg/day.

MANAGEMENT: The possibility of diminished therapeutic effects of oxcarbazepine should be considered when used in combination with potent CYP450 inducers such as carbamazepine, phenobarbital, phenytoin, primidone (which is metabolized to phenobarbital), rifampin, and St. John's wort. Close clinical and laboratory monitoring is recommended whenever a CYP450 inducer is added to or withdrawn from oxcarbazepine therapy, and the dosage adjusted as necessary.

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Oxcarbazepine Suspension

Generic Name: oxcarbazepine

Brand name: Oxtellar XR, Trileptal

Synonyms: Oxcarbazepine, OXcarbazepine

What is Oxcarbazepine Suspension?