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Carbamazepine Extended-Release Capsules (Carbatrol) and Pexidartinib

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Pexidartinib and the possibility of their joint administration.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Pexidartinib

Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration of pexidartinib with strong CYP450 3A4 inducers may decrease the plasma concentrations and therapeutic effects of pexidartinib. The proposed mechanism is induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of pexidartinib. Concomitant administration of rifampin, a strong CYP450 3A4 inducer, decreased pexidartinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 33% and 65%, respectively. The effect of coadministration with a moderate CYP450 3A4 inducer on pexidartinib pharmacokinetics is unknown. MANAGEMENT: The use of pexidartinib with strong CYP450 3A4 inducers is not recommended. References "Product Information. Turalio (pexidartinib)." Daiichi Sankyo, Inc., Parsippany, NJ.

Professional:

GENERALLY AVOID: Coadministration of pexidartinib with strong CYP450 3A4 inducers may decrease the plasma concentrations and therapeutic effects of pexidartinib. The proposed mechanism is induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of pexidartinib. Concomitant administration of rifampin, a strong CYP450 3A4 inducer, decreased pexidartinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 33% and 65%, respectively. The effect of coadministration with a moderate CYP450 3A4 inducer on pexidartinib pharmacokinetics is unknown.

MANAGEMENT: The use of pexidartinib with strong CYP450 3A4 inducers is not recommended.

References

"Product Information. Turalio (pexidartinib)." Daiichi Sankyo, Inc., Parsippany, NJ.

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Pexidartinib

Generic Name: pexidartinib

Brand name: Turalio

Synonyms: n.a.

What is Pexidartinib?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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