Carbamazepine Extended-Release Capsules (Carbatrol) and Prednisolone Oral Solution
Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Prednisolone Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:CarBAMazepine may reduce the blood levels of prednisoLONE, which may make the medication less effective in treating your condition. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Carbamazepine may decrease the plasma concentrations and systemic effects of both endogenous and exogenous corticosteroids. The mechanism is accelerated corticosteroid metabolism due to induction of the CYP450 3A4 enzymatic pathway by carbamazepine.
MANAGEMENT: Patients treated concomitantly with carbamazepine may require higher dosages of corticosteroids or adrenocorticotropic agents. Pharmacologic response to these agents should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy in patients stabilized on their existing corticosteroid or adrenocorticotropic regimen, and the dosage(s) adjusted as necessary.
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- Privitera MR, Greden JF, Gardner RW, Ritchie JC, Calrroll BJ "Interference by carbamazepine with the dexamethasone suppresion test." Biol Psychiatry 17 (1982): 611-20
- Keitner GI, Fruzzetti AE, Miller IW, Norman WH, Brown WA "The effect of anticonvulsants on the dexamethasone suppression test." Can J Psychiatry 34 (1989): 441-3
- Spina E, Pisani F, Perucca E "Clinically significant pharmacokinetic drug interactions with carbamazepine - an update." Clin Pharmacokinet 31 (1996): 198-214
- Olivesi A "Modified elimination of prednisolone in epileptic patients on carbamazepine monotherapy, and in women using low-dose oral contraceptives." Biomed Pharmacother 40 (1986): 301-8
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: prednisolone
Brand name: Flo-Pred, Millipred, Millipred DP, Orapred, Orapred ODT, Pediapred, Veripred 20, Prelone, Hydeltra-TBA, Hydeltrasol, Key-Pred, Cotolone, Depo-Predate, Predicort-50, Predalone 50, Predacort 50, Predate-50, Predaject-50, Pred-Ject-50, Key-Pred SP, Medicort, Predicort RP, Pri-Cortin 50, Predcor, Bubbli-Pred, AsmalPred Plus, Flo-Pred Oral Suspension
Synonyms: Prednisolone, PrednisoLONE (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine Extended-Release Capsules (Carbatrol)-Prednisolone Orally Disintegrating Tablets
- Carbamazepine Extended-Release Capsules (Carbatrol)-Prednisolone Sodium Phosphate
- Carbamazepine Extended-Release Capsules (Carbatrol)-Prednisolone Sodium Phosphate eent
- Carbamazepine Extended-Release Capsules (Carbatrol)-Prednisolone Sodium Phosphate Ophthalmic Solution
- Carbamazepine Extended-Release Capsules (Carbatrol)-Prednisolone Sodium Phosphate Oral Solution
- Carbamazepine Extended-Release Capsules (Carbatrol)-Prednisolone Syrup
- Prednisolone Oral Solution-Carbamazepine Extended-Release Capsules (Equetro)
- Prednisolone Oral Solution-Carbamazepine Extended-Release Tablets
- Prednisolone Oral Solution-Carbamazepine Intravenous
- Prednisolone Oral Solution-Carbamazepine Oral Suspension
- Prednisolone Oral Solution-Carbamazepine Tablets
- Prednisolone Oral Solution-Carbaphen 12