Drug search by name

Carbamazepine Extended-Release Capsules (Carbatrol) and Rapiflux

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Rapiflux and the possibility of their joint administration.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Rapiflux

Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking carBAMazepine, tell your doctor if you also use FLUoxetine. You may need dose adjustments or special tests in order to safely take both medications together. You should notify your doctor if you have symptoms of nausea, visual problems, dizziness, poor coordination, uncontrollable shivering, agitation, restlessness, or high blood pressure. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Fluoxetine may inhibit the hepatic metabolism of carbamazepine. Carbamazepine toxicity is possible. Data have been conflicting and one study has reported no significant pharmacokinetic interaction. A case of toxic serotonin syndrome has occurred in one patient who was taking both carbamazepine and fluoxetine.

MANAGEMENT: Until more information is available, close observation for clinical and laboratory evidence of carbamazepine toxicity is recommended. Dose adjustments may be required. Patients should be advised to report possible symptoms of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) or serotonin syndrome (uncontrollable shivering, agitation, incoordination, restlessness, involuntary movements, hyperreflexia, and hyperarousal).

References

Dursun SM, Mathew VM, Reveley MA "Toxic serotonin syndrome after fluoxetine plus carbamazepine." Lancet 342 (1993): 442-3
Pearson HJ "Interaction of fluoxetine with carbamazepine." J Clin Psychiatry 51 (1990): 126
Gidal BE, Anderson GD, Seaton TL, Miyoshi HR, Wilenksy AJ "Evaluation of the effect of fluoxetine on the formation of carbamazepine epoxide." Ther Drug Monit 15 (1993): 405-9
Grimsley SR, Jann MW, Carter JG, et al "Increased carbamazepine plasma concentrations after fluoxetine coadministration." Clin Pharmacol Ther 50 (1991): 10-5
Spina E, Avenoso A, Pollicino AM, Caputi AP, Fazio A, Pisani F "Carbamazepine coadministration with fluoxetine or fluvoxamine." Ther Drug Monit 15 (1993): 247-50

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Rapiflux

Generic Name: fluoxetine

Brand name: Prozac, Prozac Weekly, PROzac Pulvules, Sarafem, Rapiflux, Selfemra

Synonyms: Rapiflux (Oral)

What is Rapiflux?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions