Carbamazepine Extended-Release Capsules (Carbatrol) and Singulair (Montelukast Tablets)
Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Singulair (Montelukast Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:CarBAMazepine may reduce the blood levels and effects of montelukast. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of hepatic CYP450 isoenzymes may decrease the plasma concentrations of montelukast, which is metabolized by CYP450 2C8, 2C9, and 3A4 . When a single 10 mg dose of montelukast was administered in combination with phenobarbital, montelukast systemic exposure (AUC) decreased by approximately 40%.
MANAGEMENT: No dosage adjustment for montelukast is recommended when used concomitantly with CYP450 inducers. However, clinical monitoring for potentially reduced therapeutic effects may be appropriate, especially for potent inducers such as carbamazepine, dexamethasone, enzalutamide, phenobarbital, phenytoin, rifamycins, and St. John's wort.
- "Product Information. Singulair (montelukast)." Merck & Co, Inc, West Point, PA.
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: montelukast
Brand name: Singulair
Synonyms: Singulair
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine Extended-Release Capsules (Carbatrol)-Sinografin
- Carbamazepine Extended-Release Capsules (Carbatrol)-Sinus & Allergy PE
- Carbamazepine Extended-Release Capsules (Carbatrol)-Sinus Congestion and Pain Daytime Cool Ice
- Carbamazepine Extended-Release Capsules (Carbatrol)-Sinus Nasal Spray
- Carbamazepine Extended-Release Capsules (Carbatrol)-Sinus Pain & Pressure
- Carbamazepine Extended-Release Capsules (Carbatrol)-Sinutab Ex-Strength
- Singulair (Montelukast Tablets)-Carbamazepine Extended-Release Capsules (Equetro)
- Singulair (Montelukast Tablets)-Carbamazepine Extended-Release Tablets
- Singulair (Montelukast Tablets)-Carbamazepine Intravenous
- Singulair (Montelukast Tablets)-Carbamazepine Oral Suspension
- Singulair (Montelukast Tablets)-Carbamazepine Tablets
- Singulair (Montelukast Tablets)-Carbaphen 12