Carbamazepine Extended-Release Capsules (Carbatrol) and Stivarga

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may significantly reduce the blood levels of regorafenib, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may decrease the plasma concentrations of regorafenib. In 22 healthy male study subjects, administration of a single 160 mg dose of regorafenib on day 7 of treatment with the potent CYP450 3A4 inducer rifampin (600 mg daily for 9 days) resulted in a 50% decrease in mean regorafenib systemic exposure (AUC) compared to administration of regorafenib alone. Additionally, there was a 264% increase in the mean AUC of the M-5 metabolite, but no change in that of the M-2 metabolite. Both metabolites have been shown to have similar in vitro pharmacological activity and steady-state concentrations as regorafenib, thus the net clinical effect of these pharmacokinetic changes is unknown.

MANAGEMENT: The use of regorafenib in combination with potent CYP450 3A4 inducers such as carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampin, and St. John's wort should generally be avoided. Alternative agents with no or minimal CYP450 3A4 induction potential are recommended whenever possible.

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Stivarga

Generic Name: regorafenib

Brand name: Stivarga

Synonyms: n.a.

What is Stivarga?