Carbamazepine Extended-Release Capsules (Carbatrol) and Thiothixene
Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Thiothixene and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using thiothixene together with carBAMazepine may decrease the effects of thiothixene. You should be closely monitored for mental status changes, including hallucinations, delusions, and confusion. Contact your doctor if you use thiothixene together with carBAMazepine. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Carbamazepine may reduce plasma levels and effects of thiothixene. The mechanism may be related to induction of the CYP450 hepatic metabolism.
MANAGEMENT: Monitoring for loss of antipsychotic control is recommended if these drugs are coadministered.
- Ereshefsky L, Saklad SR, Watanabe MD, Davis CM, Jann MW "Thiothixene pharmacokinetic interactions: a study of hepatic enzyme inducers, clearance inhibitors, and demographic variables." J Clin Psychopharmacol 11 (1991): 296-301
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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