Carbamazepine Extended-Release Capsules (Carbatrol) and Tiagabine Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using tiaGABine together with carBAMazepine may alter the effects of tiaGABine. Contact your doctor if you experience loss of seizure control or other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Population pharmacokinetic studies indicate that tiagabine clearance is 60% greater in patients receiving concomitant carbamazepine with or without other enzyme inducing antiepileptic drugs (AEDs). The mechanism is thought to be induction of the CYP450 3A4 metabolism of tiagabine by carbamazepine. According to the manufacturer adequate and controlled clinical studies were conducted in patients receiving concomitant enzyme inducing AEDs.

MANAGEMENT: Clinical and laboratory monitoring may be necessary if these medications are used together, especially if carbamazepine is started or stopped in a patient stabilized on tiagabine. Patients should be advised to notify their physician if they experience loss of seizure control.

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Tiagabine Tablets

Generic Name: tiagabine

Brand name: Gabitril

Synonyms: Tiagabine, TiaGABine

What is Tiagabine Tablets?