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Carbamazepine Extended-Release Capsules (Carbatrol) and Vecuronium

Determining the interaction of Carbamazepine Extended-Release Capsules (Carbatrol) and Vecuronium and the possibility of their joint administration.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Vecuronium

Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using carBAMazepine together with vecuronium may decrease the effects of vecuronium. Close observation is recommended if you are using both medications. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Carbamazepine may reduce the effects or duration of nondepolarizing neuromuscular blocking agents. The mechanism is unknown.

MANAGEMENT: Close observation for decreased neuromuscular blocking effect is recommended if a patient on carbamazepine must receive a nondepolarizing neuromuscular blocking agent.

References

Roth S, Ebrahim ZY "Resistance to pancuronium in patients receiving carbamazepine." Anesthesiology 66 (1987): 691-3
Tempelhoff R, Modica PA, Jellish WS, Spitznagel EL "Resistance to atracurium-induced neuromuscular blockade in patients with intractable seizure disorders treated with anticonvulsants." Anesth Analg 71 (1990): 665-9
Whalley DG, Ebrahim Z "Influence of carbamazepine on the dose-response relationship of vecuronium." Br J Anaesth 72 (1994): 125-6
Norman J "Resistance to vecuronium." Anaesthesia 48 (1993): 1068-9

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?

Vecuronium

Generic Name: vecuronium

Brand name: Vecuronium Bromide, Norcuron

Synonyms: n.a.

What is Vecuronium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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