Carbamazepine Extended-Release Capsules (Equetro) and Viramune (Nevirapine Tablets)
Determining the interaction of Carbamazepine Extended-Release Capsules (Equetro) and Viramune (Nevirapine Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using carBAMazepine together with nevirapine may decrease the effects of both medications. Contact your doctor if your condition changes or if you experience seizures and other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of carbamazepine and nevirapine may result in decreased plasma concentrations of both drugs. Since both are substrates as well as inducers of CYP450 3A4, it is conceivable that each may increase metabolism of the other. However, data are limited. In four healthy, nonpregnant women, administration of a single 200 mg dose of nevirapine with 400 mg of carbamazepine resulted in a median decrease of 18.8 hours (range 15.6 to 38.0 hours) in the elimination half-life of nevirapine compared to administration alone. The decrease in nevirapine half-life led to faster undetectable nevirapine levels (median reduction in time to undetectable levels was 4 days; range 3.0 to 7.0 days), which the authors of the study suggest might reduce the risk of resistance development in pregnant women treated with single-dose nevirapine for prevention of vertical HIV transmission. However, the effect of the interaction on nevirapine during prolonged administration as part of highly active antiretroviral therapy (HAART) is unknown. In addition, the effect of nevirapine on carbamazepine pharmacokinetics has not been reported.
MANAGEMENT: Caution is advised during coadministration of carbamazepine and nevirapine. Pharmacologic effects and serum drug concentrations should be monitored more closely whenever either drug is added to or withdrawn from therapy.
- "Product Information. Viramune (nevirapine)." Boehringer-Ingelheim, Ridgefield, CT.
- "Product Information. Tegretol (carbamazepine)." Novartis Pharmaceuticals, East Hanover, NJ.
- L'homme RF, Dijkema T, van der Ven AJ, Burger DM "Enzyme inducers reduce elimination half-life after a single dose of nevirapine in healthy women." J Acquir Immune Defic Syndr 43 (2006): 193-6
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: nevirapine
Brand name: Viramune, Viramune XR
Synonyms: Viramune
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine Extended-Release Capsules (Equetro)-Viramune O/S
- Carbamazepine Extended-Release Capsules (Equetro)-Viramune Suspension
- Carbamazepine Extended-Release Capsules (Equetro)-Viramune XR
- Carbamazepine Extended-Release Capsules (Equetro)-Virasal
- Carbamazepine Extended-Release Capsules (Equetro)-Virasal Topical
- Carbamazepine Extended-Release Capsules (Equetro)-Viravan P
- Viramune (Nevirapine Tablets)-Carbamazepine Extended-Release Tablets
- Viramune (Nevirapine Tablets)-Carbamazepine Intravenous
- Viramune (Nevirapine Tablets)-Carbamazepine Oral Suspension
- Viramune (Nevirapine Tablets)-Carbamazepine Tablets
- Viramune (Nevirapine Tablets)-Carbaphen 12
- Viramune (Nevirapine Tablets)-Carbaphen CH