Carbamazepine Intravenous and Prestalia

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may reduce the blood levels and effects of amLODIPine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with carbamazepine may decrease the plasma concentrations and pharmacologic effects of calcium channel blockers (CCBs), especially the dihydropyridines (e.g., amlodipine, felodipine, nicardipine, nifedipine, nimodipine, nisoldipine). The proposed mechanism is carbamazepine induction of CYP450-mediated metabolism. In one study, the relative bioavailability of felodipine in 10 subjects receiving enzyme-inducing anticonvulsants (including four on carbamazepine alone and three on carbamazepine with phenytoin) was found to be just 6.6% that of control subjects, which represented less than 1% systemic availability of the oral dose. Likewise, in eight patients with epilepsy receiving long-term enzyme-inducing anticonvulsant therapy (including four on carbamazepine with either phenytoin, phenobarbital, or clobazam), systemic exposure (AUC) to a single 60 mg dose of nimodipine was reported to be approximately 7-fold lower than in control subjects. A case report describes loss of blood pressure control in association with undetectable nilvadipine plasma concentrations 3 days after increasing carbamazepine dosage to 600 mg/day. Nilvadipine levels increased after carbamazepine was discontinued and the patient's blood pressure returned to normal after about 2 weeks.

MANAGEMENT: Caution is advised if dihydropyridine CCBs must be used concomitantly with carbamazepine. Pharmacologic response should be monitored more closely following the initiation, discontinuation or change of dosage of carbamazepine, and the CCB dosage adjusted as necessary.

Carbamazepine Intravenous

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Intravenous?

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?