Carbamazepine Oral Suspension and Fesoterodine Fumarate
Determining the interaction of Carbamazepine Oral Suspension and Fesoterodine Fumarate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:CarBAMazepine may reduce the blood levels and effects of fesoterodine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of fesoterodine's active metabolite, 5-hydroxymethyl tolterodine, which is partially metabolized by the isoenzyme. Following induction of CYP450 3A4 with rifampin 600 mg once a day, 5-hydroxymethyl tolterodine peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 70% and 75%, respectively, after oral administration of fesoterodine 8 mg. The effects of less potent CYP450 3A4 inducers were not examined.
MANAGEMENT: No dosing adjustments are recommended when fesoterodine is used with CYP450 3A4 inducers. However, the possibility of diminished therapeutic effects should be considered.
- "Product Information. Toviaz (fesoterodine)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: fesoterodine
Brand name: Toviaz
Synonyms: Fesoterodine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine Oral Suspension-Fesoterodine Tablets
- Carbamazepine Oral Suspension-Fetzima
- Carbamazepine Oral Suspension-Fetzima Titration
- Carbamazepine Oral Suspension-Fetzima Titration Pack
- Carbamazepine Oral Suspension-Feverall
- Carbamazepine Oral Suspension-Feverall rectal
- Fesoterodine Fumarate-Carbamazepine Tablets
- Fesoterodine Fumarate-Carbaphen 12
- Fesoterodine Fumarate-Carbaphen CH
- Fesoterodine Fumarate-Carbaphen Ped CH
- Fesoterodine Fumarate-Carbastat
- Fesoterodine Fumarate-Carbatrol