Carbamazepine Tablets and Tofacitinib Citrate
Determining the interaction of Carbamazepine Tablets and Tofacitinib Citrate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using tofacitinib together with carBAMazepine. Combining these medications may reduce the blood levels and effects of tofacitinib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of tofacitinib, which is primarily metabolized by the isoenzyme. The interaction may result in loss of or reduced clinical response. In study subjects, administration with the potent CYP450 3A4 inducer rifampin decreased tofacitinib peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 75% compared to administration of tofacitinib alone.
MANAGEMENT: The use of tofacitinib in combination with potent CYP450 3A4 inducers should generally be avoided. Alternative agents with no or minimal CYP450 3A4 induction potential are recommended whenever possible. The extent to which moderate CYP450 3A4 inducers interact with tofacitinib is unknown.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Xeljanz (tofacitinib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Carbamazepine, CarBAMazepine
Generic Name: tofacitinib
Brand name: Xeljanz, Xeljanz XR
Synonyms: Tofacitinib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carbamazepine Tablets-Tofacitinib Extended-Release Tablets
- Carbamazepine Tablets-Tofacitinib Tablets
- Carbamazepine Tablets-Tofranil
- Carbamazepine Tablets-Tofranil injection
- Carbamazepine Tablets-Tofranil-PM
- Carbamazepine Tablets-Tol-Tab
- Tofacitinib Citrate-Carbaphen 12
- Tofacitinib Citrate-Carbaphen CH
- Tofacitinib Citrate-Carbaphen Ped CH
- Tofacitinib Citrate-Carbastat
- Tofacitinib Citrate-Carbatrol
- Tofacitinib Citrate-Carbatuss