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Carbidopa, Levodopa and Entacapone and Reserpine

Determining the interaction of Carbidopa, Levodopa and Entacapone and Reserpine and the possibility of their joint administration.

Check result:
Carbidopa, Levodopa and Entacapone <> Reserpine
Relevance: 26.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that reserpine may block the antiparkinsonian effects of levodopa. The mechanism is believed to be reserpine-induced depletion of brain dopamine. There is little clinical evidence for this theoretical interaction. In general, however, alternative antihypertensive therapy is recommended for patients in whom levodopa is required.

References
  • Bianchine JR, Sunyapridakul L "Interactions between levodopa and other drugs: significance in the treatment of Parkinson's disease." Drugs 6 (1973): 364-88
  • Cotzias GC, Papavasiliou PS, Gellene R "L-dopa in Parkinson's syndrome." N Engl J Med 281 (1969): 272
Carbidopa, Levodopa and Entacapone

Generic Name: carbidopa / entacapone / levodopa

Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo

Synonyms: Carbidopa, entacapone, and levodopa, Levodopa, Carbidopa, and Entacapone

Reserpine

Generic Name: reserpine

Brand name:

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle