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Carbocaine HCl and Exparel

Determining the interaction of Carbocaine HCl and Exparel and the possibility of their joint administration.

Check result:

Carbocaine HCl <> Exparel

Relevance: 10.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Bupivacaine liposome and mepivacaine should not be mixed together or injected into the same area at the same time. Bupivacaine liposome is a specialized formulation that releases the medication into the surrounding tissue at a controlled rate. When exposed to other medications or solutions, the release rate can be altered.

Professional:

ADJUST DOSING INTERVAL: Nonbupivacaine-based local anesthetics including lidocaine may cause an immediate release of bupivacaine from the liposome suspension when administered together locally.

MANAGEMENT: Bupivacaine liposome injectable suspension should not be admixed with lidocaine or other nonbupivacaine-based local anesthetics. Bupivacaine liposome injectable suspension may be locally administered after at least 20 minutes following the local administration
of lidocaine.

References

"Product Information. Exparel (bupivacaine liposome)." Pacira Pharmaceuticals Inc, San Diego, CA.

Carbocaine HCl

Generic Name: mepivacaine

Brand name: Carbocaine HCl, Polocaine, Polocaine-MPF, Scandonest, Carbocaine, Polocaine DENTAL, Carbocaine 2% with Neo-Cobefrin, Polocaine Dental, Scandonest 2% L, Carbocaine Preservative-Free, Scandonest 3% Plain

Synonyms: Carbocaine

What is Carbocaine HCl?

Exparel

Generic Name: bupivacaine liposome

Brand name: Exparel

Synonyms: n.a.

What is Exparel?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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