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Carboplatin and Etoposide

Determining the interaction of Carboplatin and Etoposide and the possibility of their joint administration.

Check result:

Carboplatin <> Etoposide

Relevance: 18.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using etoposide together with CARBOplatin may increase the effects of etoposide. Contact your doctor if you experience severe nausea and vomiting, fever, chills, sore throat, flu symptoms, easy bruising, or extreme weakness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with carboplatin or cisplatin may increase the systemic exposure of etoposide. The exact mechanism of interaction is unknown but may involve inhibition of etoposide metabolism. In one study, the median clearance of etoposide in 14 pediatric patients receiving concomitant therapy with high-dose carboplatin (400 to 700 mg/m2 given on alternate days of etoposide) was substantially lower than values previously reported in either children or adults. Higher etoposide concentrations were significantly associated with longer time to recovery of hematopoietic function. The interaction has also been reported with cisplatin during acute but not chronic administration.

MANAGEMENT: During concomitant therapy with carboplatin or cisplatin, patients should be observed for potentially increased toxicity of etoposide (e.g., myelosuppression, stomatitis, mucositis, alopecia, hepatotoxicity), and the dosage adjusted accordingly as necessary.

References

Relling MV, McLeod HL, Bowman LC, Santana VM "Etoposide pharmacokinetics and pharmacodynamics after acute and chronic exposure to cisplatin." Clin Pharmacol Ther 56 (1994): 503-11
Rodman JH, Murry DJ, Madden T, Santana VM "Altered etoposide pharmacokinetics and time to engraftment in pediatric patients undergoing autologous bone marrow transplantation." J Clin Oncol 12 (1994): 2390-7
McLeod HL "Clinically relevant drug-drug interactions in oncology." Br J Clin Pharmacol 45 (1998): 539-44

Carboplatin

Generic Name: carboplatin

Brand name: Paraplatin, CARBOplatin Novaplus

Synonyms: CARBOplatin

What is Carboplatin?

Etoposide

Generic Name: etoposide

Brand name: VePesid, Etopophos, Toposar

Synonyms: n.a.

What is Etoposide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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