Carboplatin and Plazomicin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Plazomicin can cause hearing loss, ringing in the ears, vertigo, and kidney problems, and combining it with CARBOplatin may increase the risks. Patients who may be particularly susceptible include the elderly and those who are dehydrated or have preexisting kidney disease. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Combining carboplatin and aminoglycosides may increase the risk of nephro- and ototoxicity. The exact mechanism of the interaction is unknown. Both carboplatin and aminoglycosides have been reported to cause renal magnesium wasting.

MANAGEMENT: In patients currently receiving carboplatin therapy, the use of less toxic antimicrobials is preferable. If carboplatin and an aminoglycoside must be used together, renal function, auditory and vestibular function, and serum magnesium should be monitored carefully.

Carboplatin

Generic Name: carboplatin

Brand name: Paraplatin, CARBOplatin Novaplus

Synonyms: CARBOplatin

What is Carboplatin?

Plazomicin

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: n.a.

What is Plazomicin?